Stem Cells and Ion Channels
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Stem Cells and Ion Channels
Once the zygote has formed by the fusion of the sperm cell with the oocyte, the early embryo quickly races through development, thereby gaining and losing several stages and types of stem cells. Only stem cells until the morula stage (∼16–32 cell stage) are called totipotent which means the ability to form a complete, new organism. In contrast, the famous embryonic stem cell derived from the in...
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Hematopoietic stem cells (HSCs) reside in bone marrow niches and give rise to hematopoietic precursor cells (HPCs). These have more restricted lineage potential and eventually differentiate into specific blood cell types. Bone marrow also contains mesenchymal stromal cells (MSCs), which present multilineage differentiation potential toward mesodermal cell types. In bone marrow niches, stem cell...
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Bone marrow mesenchymal stem cells (MSCs) are used as a cell source for cardiomyoplasty; however, the cellular electrophysiological properties are not fully understood. The present study was to investigate the functional ionic channels in undifferentiated mouse bone marrow MSCs using whole cell patch-voltage clamp technique, RT-PCR, and Western immunoblotting analysis. We found that three types...
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Ion channels in epithelial cells serve to move ions, and in some cases fluid, between compartments of the body. This function of the transfer of material is fundamentally different from that of the transfer of information, which is the main job of most channels in excitable cells. Nevertheless the basic construction of the channels is similar in many respects in the two tissue types. This chapt...
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ژورنال
عنوان ژورنال: Stem Cells International
سال: 2013
ISSN: 1687-966X,1687-9678
DOI: 10.1155/2013/238635